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BioReliance Launches Genotox Screening Service

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By: Tim Wright

Editor-in-Chief, Contract Pharma

BioReliance Corp. has partnered with Gentronix to offer their GreenScreen HC in vitro assay as part of its genotoxicity screening services. GreenScreen HC, in conjunction with Ames II assays, allows pharmaceutical companies to test for genotoxic potential earlier in the preclinical development process, using only a few milligrams of test compound, according to the company.

John Nicholson, chairman and chief executive officer of Gentronix, said, “We are delighted to complete this agreement with BioReliance, a company regarded as a global leader in genetic toxicology testing services.”

“This new high-throughput assay from Gentronix furthers BioReliance’s ability to meet customer demand for faster and more-effective genotoxic screening services,” said David Bruning, senior director, toxicology operations at BioReliance. “The GreenScreen HC and Ames II assays, when combined, offer highly predictive and sensitive detection of genotoxic compounds while minimizing false positives seen with other in vitro assays, accelerating the development process.”

GreenScreen HC is a human cell-based genotoxicity screening assay that links the regulation of the human Growth Arrest and DNA Damage (GADD45a) gene to the production of Green Fluorescent Protein (GFP). Cells that have incurred DNA damage upon exposure to a test compound express higher levels of detectable GFP.

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